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Mendelian Randomization : Methods for Causal Inference Using Genetic Variants
Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides thorough coverage of the methods and practical elements of Mendelian randomization analysis.It brings together diverse aspects of Mendelian randomization from the fields of epidemiology, statistics, genetics, and bioinformatics. Through multiple examples, the first part of the book introduces the reader to the concept of Mendelian randomization, showing how to perform simple Mendelian randomization investigations and interpret the results.The second part of the book addresses specific methodological issues relevant to the practice of Mendelian randomization, including robust methods, weak instruments, multivariable methods, and power calculations.The authors present the theoretical aspects of these issues in an easy-to-understand way by using non-technical language.The last part of the book examines the potential for Mendelian randomization in the future, exploring both methodological and applied developments. FeaturesOffers first-hand, in-depth guidance on Mendelian randomization from leaders in the fieldMakes the diverse aspects of Mendelian randomization understandable to newcomersIllustrates technical details using data from applied analysesDiscusses possible future directions for research involving Mendelian randomizationSoftware code is provided in the relevant chapters and is also available at the supplementary websiteThis book gives epidemiologists, statisticians, geneticists, and bioinformaticians the foundation to understand how to use genetic variants as instrumental variables in observational data. New in Second Edition: The second edition of the book has been substantially re-written to reduce the amount of technical content, and emphasize practical consequences of theoretical issues.Extensive material on the use of two-sample Mendelian randomization and publicly-available summarized data has been added.The book now includes several real-world examples that show how Mendelian randomization can be used to address questions of disease aetiology, target validation, and drug development
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How we Get Mendel Wrong, and Why it Matters : Challenging the narrative of Mendelian genetics
This book illustrates that the stereotypical representations of Gregor Mendel and his work misrepresent his findings and their historical context.The author sets the historical record straight and provides scientists with a reference guide to the respective scholarship in the early history of genetics.The overarching argument is twofold: on the one hand, that we had better avoid naïve hero-worshipping and understand each historical figure, Mendel in particular, by placing them in the actual sociocultural context in which they lived and worked; on the other hand, that we had better refrain from teaching in schools the naive Mendelian genetics that provided the presumed “scientific” basis for eugenics. Key FeaturesCorrects the distorting stereotypical representations of Mendelian genetics and provides an authentic picture of how science is done, focusing on Gregor Mendel and his actual contributions to scienceExplains how the oversimplifications of Mendelian genetics were exploited by ideologues to provide the presumed “scientific” basis for eugenicsProposes a shift in school education from teaching how the science of genetics is done using model systems to teaching the complexities of development through which heredity is materialized
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What is Mendelian genetics?
Mendelian genetics is a set of principles established by Gregor Mendel in the 19th century that describes the inheritance of traits from parents to offspring. These principles include the concepts of dominant and recessive alleles, segregation, and independent assortment. Mendelian genetics forms the foundation of modern genetics and helps explain how traits are passed down through generations in a predictable manner.
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Which Mendelian rule fits?
The Mendelian rule that fits is the principle of segregation. This rule states that during the formation of gametes, the two alleles for a gene segregate from each other so that each gamete carries only one allele for each gene. This means that offspring receive one allele from each parent, and the combination of alleles determines the genetic traits of the offspring. This principle helps explain the inheritance patterns of single gene traits in offspring.
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What are the Mendelian inheritance rules?
The Mendelian inheritance rules are a set of principles that describe how genetic traits are passed from parents to offspring. These rules include the principles of dominance, segregation, and independent assortment. Dominance refers to the fact that one allele of a gene may mask the expression of another allele. Segregation describes how alleles separate and are randomly distributed into gametes during meiosis. Independent assortment states that alleles of different genes are inherited independently of each other. These rules form the basis of classical genetics and are fundamental to understanding inheritance patterns in organisms.
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What are the Mendelian laws in genetics?
The Mendelian laws in genetics refer to the principles of inheritance discovered by Gregor Mendel in the 19th century. These laws include the law of segregation, which states that each individual has two alleles for a trait, and these alleles separate during the formation of gametes. The law of independent assortment states that the inheritance of one trait is not dependent on the inheritance of another trait. Finally, the law of dominance states that one allele can be dominant over another, determining the phenotype of the organism. These laws laid the foundation for our understanding of genetic inheritance.
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What does the fourth Mendelian rule state?
The fourth Mendelian rule, also known as the law of independent assortment, states that the inheritance of one trait is independent of the inheritance of another trait. This means that the alleles for different genes are passed on to offspring independently of one another, and the assortment of one pair of alleles does not influence the assortment of another pair of alleles. This rule helps explain the variety of genetic combinations that can occur in offspring, contributing to genetic diversity within a population.
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What does the 5th Mendelian rule state?
The 5th Mendelian rule states that genes located on different chromosomes assort independently during meiosis. This means that the inheritance of one gene does not affect the inheritance of another gene located on a different chromosome. This principle is known as Mendel's Law of Independent Assortment and helps explain the genetic diversity observed in offspring.
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How does the 3rd Mendelian rule work?
The third Mendelian rule, also known as the Law of Independent Assortment, states that different genes for different traits are inherited independently of each other. This means that the inheritance of one gene does not affect the inheritance of another gene. During meiosis, homologous chromosomes randomly assort and separate into different gametes, leading to the independent inheritance of different traits. This rule helps explain the genetic variability seen in offspring and the inheritance patterns of multiple traits.
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Do you need help with Mendelian rules?
Yes, I can help you understand Mendelian rules. Mendelian rules refer to the principles of inheritance discovered by Gregor Mendel, which include concepts such as dominant and recessive alleles, segregation, and independent assortment. I can explain these concepts and help you understand how they apply to genetic inheritance. If you have specific questions or need further clarification on any aspect of Mendelian rules, feel free to ask!
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